Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function
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چکیده
منابع مشابه
Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function.
The isthmic organizer (IsO) is a signaling center that specifies the correct and distinct embryonic development of the dopaminergic midbrain and serotonergic hindbrain. The IsO is a linear boundary between the two brain regions, emerging at around embryonic day 7-8 of murine embryonic development, that shapes its surroundings through the expression of instructive signals such as Wnt and growth ...
متن کاملZebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer.
The mesencephalic and metencephalic region (MMR) of the vertebrate central nervous system develops in response to signals produced by the isthmic organizer (IsO). We have previously reported that the LIM homeobox transcription factor Lmx1b is expressed within the chick IsO, where it is sufficient to maintain expression of the secreted factor wnt1. In this paper, we show that zebrafish express t...
متن کاملHes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain.
The isthmic organizer, which is located at the midbrain-hindbrain boundary, plays an essential role in development of the midbrain and anterior hindbrain. It has been shown that homeobox genes regulate establishment of the isthmic organizer, but the mechanism by which the organizer is maintained is not well understood. Here, we found that, in mice doubly mutant for the basic helix-loop-helix ge...
متن کاملDevelopment/Plasticity/Repair Lmx1b-Controlled Isthmic Organizer Is Essential for Development of Midbrain Dopaminergic Neurons
Chao Guo,1* Hai-Yan Qiu,1,2* Ming Shi,1 Ying Huang,1 Randy L. Johnson,3 Marcelo Rubinstein,4 Sheng-Di Chen,2 and Yu-Qiang Ding1 1Institute of Neuroscience, Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai 200031, China, 2Department of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China, 3Department of Biochemistry and Molecula...
متن کاملLmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons.
The LIM homeodomain transcription factor Lmx1b has been suggested to be required for the differentiation of midbrain dopaminergic (mDA) neurons. However, whether the loss of mDA neurons in Lmx1b(-/-) mice is due to its intrinsic role in the mDA lineage or to a consequence of the malformations caused by the earlier mid/hindbrain patterning defects remains to be clarified. We report here that Lmx...
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ژورنال
عنوان ژورنال: Biology Open
سال: 2016
ISSN: 2046-6390
DOI: 10.1242/bio.015032